Metabolomic Tools for Secondary Metabolite Discovery from Marine Microbial Symbionts
نویسندگان
چکیده
منابع مشابه
Metabolomic Tools for Secondary Metabolite Discovery from Marine Microbial Symbionts
Marine invertebrate-associated symbiotic bacteria produce a plethora of novel secondary metabolites which may be structurally unique with interesting pharmacological properties. Selection of strains usually relies on literature searching, genetic screening and bioactivity results, often without considering the chemical novelty and abundance of secondary metabolites being produced by the microor...
متن کاملMicrobial symbionts of marine invertebrates: opportunities for microbial biotechnology.
Marine invertebrates are sources of a diverse array of bioactive metabolites with great potential for development as drugs and research tools. In many cases, microorganisms are known or suspected to be the biosynthetic source of marine invertebrate natural products. The application of molecular microbiology to the study of these relationships will contribute to basic biological knowledge and fa...
متن کاملUsing Molecular Networking for Microbial Secondary Metabolite Bioprospecting
The oceans represent an understudied resource for the isolation of bacteria with the potential to produce novel secondary metabolites. In particular, actinomyces are well known to produce chemically diverse metabolites with a wide range of biological activities. This study characterised spore-forming bacteria from both Scottish and Antarctic sediments to assess the influence of isolation locati...
متن کاملThe secondary metabolite bioinformatics portal: Computational tools to facilitate synthetic biology of secondary metabolite production
Natural products are among the most important sources of lead molecules for drug discovery. With the development of affordable whole-genome sequencing technologies and other 'omics tools, the field of natural products research is currently undergoing a shift in paradigms. While, for decades, mainly analytical and chemical methods gave access to this group of compounds, nowadays genomics-based m...
متن کاملMolecular Tools for the Study of Marine Microbial Diversity
1. The Importance of Biodiversity Research in the Marine Environment 2. What Questions can be Answered Using Molecular Biology Techniques? 3. Evaluating Marine Biodiversity by Sequence Analysis and Fingerprinting Methods 3.1. Sequence Analysis 3.1.1. Which Genes to Select? 3.1.2. How to Generate Sequence Data? 3.1.3. Determining Biodiversity in an Environmental Sample by Sequence Analysis 3.1.4...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Marine Drugs
سال: 2014
ISSN: 1660-3397
DOI: 10.3390/md12063416